Real estate notes | TribLIVE

By Sam Spatter

Published: Saturday, November 24, 2012, 8:57?p.m.
Updated 12 hours ago

? Pittsburgh City Council will hold a hearing Monday on a proposed zoning classification for Bakery Square in the Larimer-East Liberty area. The SP-9 (specially planned district) classification would be for Bakery Square and the Bakery Square 2.0 project across Penn Avenue, where Reizenstein School is. The hearing is in the Fifth Floor hearing room, City-County Building, 414 Grant St., Downtown.

? A hearing on a request from the Pittsburgh Housing Authority will be held by City Council at 2 p.m. Tuesday. The hearing involves construction of 300 townhomes to replace Addison Terrace public housing on 43 acres bounded by Devillers, Rose and Kirkpatrick streets and Bentley Drive in the Hill District. The development will include roads, utilities and a community building. There will be 184 townhouse units in the first phase.

? Charles Menzock will seek approval Thursday from the Pittsburgh Zoning Board of Adjustment to use a one-story structure at 1500 Chateu St., North Side, for a manufacturing and assembly operation. The Duetscher Sport Verin Von 1924 of Pittsburgh needs variances to use a one-story structure at 2461 Underwood St. as a club. Dah Partners LP wants to use 6814 Kelly St. for outdoor recreation and entertainment, and the corner of Hamilton and Dallas avenues, Homewood, for 71 parking spaces. Ethel Stubbs wants to use a portion of a lot at 7240 Hamilton Ave., Homewood, for outdoor hot dog sales. Abraham Jastin seeks approval for a three-story residential structure at 3247 Ward St., Oakland, that would have four units and a one-story, three-car garage.

? Eco-Structure Magazine has given PNC Financial Services Group an Evergreen Award for its sustainably designed 32-story headquarters Downtown, The Tower at PNC Plaza, a 781,000-square-foot building, is expected to be completed in 2015.

? Pittsburgh Public Market has a new restaurant, La Palapa Mexican Cuisine, operated by Jesus Martinez. He said, ?I wanted to open a window to the Mexican culture, cuisine and costumes through the delicious mix of smells and flavors of Mexican cuisine, just like we have them back home.?

? The Community Foundation of Fayette County is accepting applications from nonprofit agencies for the 2012 Growth Fund for five target areas ? Uniontown, Connellsville, Ohiopyle, Point Marion and Brownsville. A workshop for applicants will be held Dec. 3 from 2 to 4:30 p.m. at the Carnegie Library, 299 S. Pittsburgh St., Connellsville. To register, contact Renee Couser at rcouser@cffayettepa.org. Deadline for applications is Dec. 14 at 4 p.m.

? Nemacolin Woodlands Resort plans to convert an arcade building in Farmington to the Lady Luck Casino, a PGCB Resorts venue. The project includes three additions to the building and will feature slots, table games, poker room, Otis & Henry Restaurant, Lone Wolf bar and other elements. Linda Lerro is handling bids for the work.

? Millcraft Center in Washington has several new tenants: American Red Cross, Katharine Thompson Alberta and Southern Care Inc.

Real Estate Gallery

? Millcraft Investments of Washington County added Timothy Hazel as general counsel. The company welcomed Bob Lewis , assistant property manager; Valarie Wichterman , accounting manager; and Charlie Brandon , internal construction supervisor.

? Coldwell Banker Real Estate Services hired Bob Hollack as a commercial sales associate.

? Prudential Preferred Realty hired sales associates Yolanda Zaid , Butler; Mary Navarro and Rob Haus , Pittsburgh; Starr Mikan , East; Bill Bangor , Greensburg; Bob Nolan , Hampton; Casie Lutz , North Hills; David McKelvey , Laurisa Mathews and Kathy DePaul-Green , Peters; Erin Forster , Sewickley; Cheri Cwynar , Thomas Stoviak and Amanda Wydra , West.

Sam Spatter is a staff writer for Trib Total Media. He can be reached at 412-320-7843 or sspatter@tribweb.com.

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Source: http://triblive.com/business/realestate/2987137-74/pittsburgh-building-hearing-estate-real-square-structure-bakery-bob-county

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Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells

Team solves birth and migration mysteries of cortex's powerful inhibitors, 'chandelier' cells

Friday, November 23, 2012

The cerebral cortex of the human brain has been called "the crowning achievement of evolution." Ironically, it is so complex that even our greatest minds and most sophisticated science are only now beginning to understand how it organizes itself in early development, and how its many cell types function together as circuits.

A major step toward this great goal in neuroscience has been taken by a team led by Professor Z. Josh Huang, Ph.D., at Cold Spring Harbor Laboratory (CSHL). Today they publish research for the first time revealing the birth timing and embryonic origin of a critical class of inhibitory brain cells called chandelier cells, and tracing the specific paths they take during early development into the cerebral cortex of the mouse brain.

These temporal and spatial sequences are regarded by Huang as genetically programmed aspects of brain development, accounting for aspects of the brain that are likely identical in every member of a given species including humans. Exceptions to these stereotypical patterns include irregularities caused by gene mutations or protein malfunctions, both of which are now being identified in people with developmental disorders and neuropsychiatric illnesses.

Chandelier cells were first noticed only 40 years ago, and in the intervening years frustratingly little has been learned about them, beyond the fact that they "hang" individually among great crowds of excitatory cells in the cortex called pyramidal neurons, and that their relatively short branches make contact with these excitatory cells. Indeed, a single chandelier cell connects, or "synapses," with as many as 500 pyramidal neurons. Noting this, the great biologist Francis Crick decades ago speculated that chandelier cells exerted some kind of "veto" power over the messages being exchanged by the much more numerous excitatory cells in their vicinity.

Born in a previously undiscovered 'country'

After three years of painstaking work that has involved using new technologies to identify and trace neural cell progenitors in ways not previously possible, and to track them as they migrate to positions in the maturing cortex, Huang and colleagues, including Dr. Hiroki Taniguchi now at the Max Planck Florida Institute, have demonstrated that chandelier cells are born in a previously unrecognized portion of the embryonic brain, which they have named the VGZ (ventral germinal zone).

Huang, who has been on a decade-long quest to develop means of learning much more about the cortex's inhibitory cells (sometimes called "interneurons"), points out that while they are far less numerous than the excitatory pyramidal cells all around them, cells including chandelier cells that inhibit or modulate excitatory-cell messages play an indispensable role in balancing message flow and ultimately in determining the functional organization of excitatory neurons into meaningful groups.

This is all the more intriguing in the case of chandelier cells, Huang explains, because of their distinctive anatomy: one cell that can regulate the messages of 500 others in its vicinity is one that we need to know about if we want to understand how brain circuits work. Unlike other inhibitory cells, chandelier cells are known to connect with excitatory cells at one particular anatomical location, of great significance: a place called the axon initial segment (AIS) ? the spot where a "broadcasting" pyramidal cell generates its transmittable message. To be able to interdict 500 "broadcasters" at this point renders a single chandelier cell a very important player in message propagation and coordination within its locality.

Because of the strategic importance of such cells throughout the cortex, it has been a source of frustration to neuroscientists that they (and other inhibitory cells) have been difficult to classify. Huang has pursued a strategy of following them from their places of birth in the emerging cortex.

Many inhibitory cells come from a large incubator area called the MGE (medial ganglionic eminence); until now, it was not known that most chandelier cells are not born there, and indeed do not emerge until after the MGE has disappeared. Only at this point does the much smaller VGZ form, providing a place where neural precursor cells specifically give rise to chandelier cells.

The team learned that manufacture of a protein encoded by a gene called Nkx2.1 is among the signals marking the birth of a chandelier cell. The gene's action, they found, is also necessary to make the cells. Nkx2.1is a transcription factor, whose expression has previously been linked to the birth of other inhibitory neuronal types. Huang's team observes that it is the timing of Nkx2.1's expression in certain precursors -- following disappearance of the MGE and appearance of the VGZ -- that enabled them to track the birth, specifically, of chandelier cells.

Highly specific migration route and cortical destinations

"In addition to being surprised to discover that chandelier cells are born 'late'?after other inhibitory cells ? in a part of the cortex we didn't know about," says Huang, "our second surprise is that once born, these cells take a very stereotyped route into the cortex and assume very specific positions, in three cortical layers." (Layers 2, 5 and 6). "This leads us to postulate that other specific cortical cell types also have specific migration routes in development."

As Huang points out, his team's new discoveries about chandelier cells have implications for disease research, since it is known that the number and connective density of chandelier cells is diminished in schizophrenia. Associations of the same type have recently been made in epilepsy.

"To know the identity of a cell type in the cortex is in effect to know the intrinsic program that distinguishes it from other cell types. In the broadest terms, we are learning about those aspects of the brain development that make us human. 'Nurture,' or experience, also has a very important role in brain development. Our work helps clarify the 'nature' part of the nature/nurture mystery that has always fascinated us," Huang says.

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"The spatial and temporal origin of chandelier cells in mouse cortex" appears online ahead of print November 22, 2012 in Science Express.

Cold Spring Harbor Laboratory: http://www.cshl.org

Thanks to Cold Spring Harbor Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/125442/Team_solves_birth_and_migration_mysteries_of_cortex_s_powerful_inhibitors___chandelier__cells

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The Tallest Building in the World, Cooking Turkey with NASA Equipment, The Most Unpopular Apple Employee, And More

Turkey day was this week, but that doesn't mean the world's stopped moving. We've got some details on the new Xbox, info on what's going to be the tallest building in the world, the answer to the question "will we run out of music," weird turkey cooking and more. Check it all out below. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/tuXqv9YVIk4/the-tallest-building-in-the-world-cooking-turkey-with-nasa-equipment-the-most-unpopular-apple-employee-and-more

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Oklahoma City Historical Homes Real Estate Market Update ...

Oklahoma City Historical Area November 2012 Real Estate Market Update

The historical areas included in this report include: Crown Heights, Edgemere, Gatewood, Heritage Hills, Mesta Park, Crestwood and Linwood.

	Current	Monthly Change
Active Listings	60	+3
Under Contract	29	-20
Sold (October)	24	+10

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• High list price: $1,800,000
• Low list price: $52,900
• Average list price: $282,042
• Median list price: $187,000

• High sales price/ft: $250.00
• Low sales price/ft: $16.46
• Average price/ft: $109.75
• Median price/ft: $100.27

• Average days-on-market: 61
• Median days-on-market: 35

Showing properties 1 - 10 of 56. See more Currently Available - Historical Area.
(all data current as of 11/23/2012)

1. 3 beds, 2 full baths

   Home size: 2,715 sq ft

   Lot size: 8,250 sqft

   Year built: 1926

   Parking spots: 1

   Days on market: 2

2. 3 beds, 2 full baths

   Home size: 2,774 sq ft

   Lot size: 7,000 sqft

   Year built: 1910

   Parking spots: 2

   Days on market: 3

3. 3 beds, 1 full, 1 part baths

   Home size: 1,650 sq ft

   Lot size: 9,405 sqft

   Year built: 1939

   Parking spots: 2

   Days on market: 6

4. 2 beds, 1 full bath

   Home size: 1,020 sq ft

   Lot size: 9,000 sqft

   Year built: 1935

   Parking spots: 1

   Days on market: 9

5. 3 beds, 2 full, 1 part baths

   Home size: 2,902 sq ft

   Lot size: 8,400 sqft

   Year built: 1936

   Parking spots: 2

   Days on market: 10

6. 3 beds, 5 full baths

   Home size: 4,173 sq ft

   Lot size: 15,002 sqft

   Year built: 1954

   Parking spots: 2

   Days on market: 12

7. 3 beds, 1 full, 1 part baths

   Home size: 1,669 sq ft

   Lot size: 7,200 sqft

   Year built: 1920

   Days on market: 13

8. 2 beds, 1 full bath

   Home size: 1,120 sq ft

   Lot size: 8,263 sqft

   Year built: 1936

   Parking spots: 1

   Days on market: 15

9. 4 beds, 2 full baths

   Home size: 2,880 sq ft

   Year built: 1910

   Parking spots: 2

   Days on market: 16

10. 4 beds, 3 full baths

    Home size: 2,535 sq ft

    Lot size: 7,000 sqft

    Year built: 1910

    Parking spots: 3

    Days on market: 16

Listing information deemed reliable but not guaranteed. Read full disclaimer.

Historical Area Homes For Sale

Historical Area Recent Price Reductions

Historical Area New Listings

Tagged as: historical homes, market data, oklahoma city real estate

Source: http://okchomesellers.com/statistics/oklahoma-city-historical-homes-real-estate-market-update-november-2012/

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GM Introduces Sail SPRINGO EV in China

General Motors Co announced the launch of its first China-developed electric car at the Guangzhou Auto Show, which will be sold for RMB 258,000 ($41,400).

The Sail SPRINGO EV was developed by Shanghai GM and the Pan Asia Technical Automotive Center (PATAC), making it the first production electric vehicle created by a Chinese joint venture.

The SPRINGO EV pure electric vehicle meets the highest global electric vehicle standards, using the latest industry battery and electric drive technology.

The Sail SPRINGO EV is well suited for urban environments. Its pure electric propulsion system delivers an exceptional driving experience that rivals traditional gasoline-powered vehicles. The vehicle?s electric motor produces minimal sound, for a distinctly peaceful commute.

Based off a new electric vehicle architecture developed by Shanghai GM in conjunction with PATAC, the Sail SPRINGO EV has an emissions-free propulsion system. Its permanent magnet electric motor is capable of producing 85 kW of power and up to 510 Nm of torque, allowing acceleration from 0 to 100 km/h (0-62 mph) from a standing start in just over 10 seconds. Pushing the Sport button provides a 20 percent boost in acceleration at the beginning and middle of the torque curve compared to pressing the accelerator in a gasoline-powered vehicle. The top speed is 130 km/h (80 mph). Its stability during high-speed cruising and cornering is optimized by a new tailored full-frame chassis with an enhanced stabilizer bar and a finely tuned suspension.

The Sail SPRINGO EV?s battery and electric drive technology were developed based on the most advanced global electric vehicle standards for maximum energy efficiency. The result is an exceptionally long electric range of 130 km (80 miles) under a variety of road conditions and 200 (127 miles) km at a constant speed of 60 km/h (37 mph), which is sufficient to meet the daily needs of most people living in urban areas.

The Sail SPRINGO EV consumes less than 15 kWh for every 100 km, which is less than most electric vehicles currently on the market. The Sail SPRINGO EV costs just RMB 4.6 per 100 km to drive when charged during lower-cost off-peak hours (between 10:00 p.m. and 6:00 a.m.).

The Sail SPRINGO EV is environmental and user friendly, with a host of advanced vehicle telematics. It can be charged using a 3.3-kW charging station or a standard household outlet. It takes approximately seven hours for the battery to be fully charged using a dedicated 220V connection. There are three charging modes available: immediate charging, time delay charging, and time delay and rate charging. This enables customers to choose the charging option that fits their needs.

Vehicle charging can also be managed and monitored remotely using a smart phone mobile app provided by Shanghai OnStar. Owners can use the app to perform a range of functions remotely, such as starting the vehicle?s heater or air conditioner. OnStar?s service system also carries out remote vehicle monitoring and analysis of other vehicle systems, and provides drivers with additional vehicle information such as tire pressure. If abnormal data is detected, the OnStar system will immediately contact the owner to provide safety information and instructions.

Yet another feature allows owners to check energy usage and remaining charge level with a touch of the Energy Leaf button. A color display, multimedia entertainment system and information display center with a 7-inch high-definition dual touchscreen offer drivers and passengers an easy-to-use interactive experience.

A world-class safety design protects Sail SPRINGO EV occupants in the event of a collision. The vehicle passed an extensive array of more than 20 collision tests during its development to verify its safety.

Developed to meet the strictest global electric vehicle safety standards, the Sail SPRINGO EV fully complies with safety requirements for pure electric vehicles in China. Its newly designed front and rear anti-collision beams made from ultra-high strength steel and its strong and comprehensive body structure protect the battery pack in the event of a collision. The battery pack and powertrain have performed normally after rigorous testing in various conditions.

All of Shanghai GM's new energy vehicles, including the Sail SPRINGO EV, will be sold through an exclusive ?Drive to Green? sales network. The first showroom is expected to open in the first half of 2013 in Shanghai. The exclusive sales and aftersales service network will be expanded to key new energy vehicle demo cities based on local market conditions and the development of the new energy vehicle industry and charging infrastructure.

The Sail SPRINGO EV will come with a vehicle warranty of three years or 80,000 km (50,000 miles), as well as a battery warranty of five years or 100,000 km (62,000 miles). Until the ?Drive to Green? sales network is established, Shanghai GM's Buick and Chevrolet service centers will provide Sail SPRINGO EV owners door-to-door service and exclusive steward service for a worry-free driving and maintenance experience.

Source: http://puregreencars.com/green-cars/100-electric/gm-introduces-sail-springo-ev-in-china.html

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Drained wetlands give off same amount of greenhouse gases as industry

ScienceDaily (Nov. 23, 2012) ? Drained wetlands in Sweden account for the same amount of greenhouse gas emissions as Swedish industry. This is shown by a summary of research from the University of Gothenburg, Sweden and the Swedish University of Agricultural Sciences.

Forests and agricultural fields on drained previous wetlands make up between five and ten percent of Sweden's surface area. When these wetlands are drained, they become a significant source of greenhouse gas emissions.

"We note that drained wetlands which have been forested or used for agricultural purposes are a significant potential source of greenhouse gases of a magnitude that is at least comparable with the industrial sector's greenhouse gas emissions in Sweden."

Emissions from these drained wetlands can be reduced, but that involves rewetting the land -- resulting in a negative impact on forestry production. According to the researchers, compromises may be necessary.

"As long as wetlands remain wet, only methane is given off," says ?sa Kasimir Klemedtsson from the Department of Earth Sciences at the University of Gothenburg. "However, for more than a hundred years land has been drained for agriculture and forestry, producing large quantities both carbon dioxide and nitrous oxide."

Together with researcher ?rjan Berglund from the Swedish University of Agricultural Sciences, Dr Kasimir Klemedtsson was commissioned by the Swedish Environmental Protection Agency during the summer and autumn of 2012 to compile information about greenhouse gases from drained wetlands.

New rules were introduced at last year's Durban Climate Change Conference with the second Kyoto Protocol phase. These rules include the possibility of reporting wetland drainage or rewetting of drained wetlands. Sweden now faces the choice of whether to include these ahead of the second Kyoto Protocol phase.

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The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/4mh71SixfEk/121123092742.htm

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5 Critical Content Marketing Mistakes That You Must Avoid ...

Content marketing i.e. creating and distributing content is one of the most effective ways to promote a business online. Businesses and marketers all over the world are using content to attract new customers. However, creating quality content regularly, takes valuable time and resources. It is thus important to do it correctly and get the most out of your efforts.

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In this article we take a look at five common content marketing mistakes that should not be left unchecked. If you want your business to benefit from content marketing, you will need to avoid these mistakes.

1. Writing For The Wrong Audience

When I first started blogging a few years ago, my content was aimed more at marketers, designers and SEO specialists as opposed to businesses. Although my content performed well and I was building a good following, I finally came to a realisation that I was not targeting the right audience.

One of the main purposes of starting a blog for me was to generate leads and sales from my Web design and Internet marketing business. It thus made sense to target businesses instead of other professionals in my niche. Finally, I had to shift focus to address businesses instead of other designers and marketers. I still write about the same topics, but I use less jargon and have had to adjust my tone to address businesses instead. It took me two years to realise this. You can learn from my experience and define your audience right from the start.

2. Poorly Crafted Headlines

Compelling headlines or titles are vital to the success of your content whether it is a blog post, an eBook or a report. Compelling headlines play a major role in determining the popularity and readership of your content.

A great headline should:

• Grab the attention of Readers
• Generate interest and compel users to read the rest of your content
• Should be clear and concise and easy to understand
• Should include keywords

You can take advantage of list posts or instructional content as they are very popular among readers and tend to be share more on social media.

Lets take a simple example.? The same headline ?methods to improve the usability of your website can be better written as ?10 Easy Ways to Improve The Usability of Your Website? which is more compelling and will grab the attention of readers.

3. Focusing On Quantity Over Quality

It is often suggested that a business or web master should publish content every day in order to get more coverage and reach. Publishing daily does have its benefits, particular on blogs. It can improve your search engine rank and drive more visitors towards your website. However it should never be at the cost of quality. Publishing quality content once a week can be equally effective for meeting your marketing objectives.

4. Not Optimising Your Content? Search Engine Optimisation

Optimising your content properly is essential to get the desired results. Both, external SEO factors such as link building and on-page optimisation are important. The importance of good on-page optimisation should not be under-estimated. Good optimisation is a must for all content produced as part of your marketing efforts. It should not be overlooked whether you are creating a blog post, press release or an article.

Source: SEOMoz. Org

Here are some SEO tips you can use:

• Choose the right keywords:
• Use Keywords in Headline
• Use Keywords in Meta title and description
• Use keywords in headings and bold text
• Optimise Image ALT descriptions
• Use in URL e.g. www.yoursitename.com/keywordphrase.html

5. Syndicating The Same Content Everywhere

It is common for businesses and marketers to distribute content on several sources in order to maximise their reach. For example, a business may post content on its blog, publish articles on article sites, create eBooks and as well as publish documents on document sharing sites. Some businesses make the mistake of publishing the same identical content on several sources. ?Although targeting multiple channels can be very effective, syndicating the exact same content everywhere should be avoided.

What About You?

Do you use content marketing to promote your business? Are you avoiding the common mistakes above? Perhaps you would like to add another suggestion to this list. Please share your response by leaving a comment below.

If you like this article, please share it!

Source: http://myventurepad.com/ksingh/152871/5-critical-content-marketing-mistakes-you-must-avoid

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